For Healthcare Professionals



IBSA specialises in the research and development, production and marketing of hyaluronic acid-based products

Sinovial Product Benefits

Raggruppa 707@2x

Long term effectiveness with greater resistance to breakdown of hyaluronidase.

Raggruppa 337@2x

Very high concentrations of hyaluronic acid, with low viscosity and ease of injection

Raggruppa 296@2x

Produced sustainably and ethically with no animal derivatives or chemical processing

Concentration % GAGs across available UK visco-supplementation products

GAG barchart

Glycosaminoglycans (GAGs) form a key role in the rheology of endogenous synovial fluid. Synovial fluid provides nourishment to hyalin cartilage, lubrication of joint surfaces and a viscoelastic environment to dissipate load bearing and sheer forces. In degenerative joint conditions, there is a reduction in synovial fluid and GAGs thus reducing these three key functions.

Providing visco-supplementation to a degenerative joint with a high GAG concentration in a hybrid cooperative complex preparation aims to restore the rheological properties of endogenous synovial fluid functions.

Domżalski, M., Migliore, A. A Review of the Clinical Effectiveness and Safety of Hybrid Cooperative Complexes in Intra-articular Viscosupplementation. Rheumatol Ther 9, 957–974 (2022).

Sinogel 3ml

Hybrid Cooperative complexes of high MW HA combined with sodium chondroitin held by hydrogen bonds

Sinovial HL 64 2ml

Hybrid Cooperative complexes of high and low MW HA held by hydrogen bonds

Sinovial HL 32 1ml

Hybrid Cooperative complexes of high and low MW HA held by hydrogen bonds